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It has been shown to have antioxidant properties (Packer 1999) as well as protective effects against glutamate excitotoxicity (Kobayashi 2000)

PBS (0.01 M) was purchased from Biosharp

Furthermore, ROS play a multitude of additional roles in initiating the T cell response, such as activating key transcription factors (e.g., NF-B, AP-1) and the mechanistic target of rapamycin complex 1 (mTORC1), the master regulator of cellular metabolism (79)